Overview
The Millipore Durapore CVGB71TP3 is a hydrophobic cartridge filter engineered for critical sterile filtration applications. With a nominal pore size of 0.22 micrometers and Code 7 device configuration, this filter reliably removes bacterial and particulate contaminants from aqueous and non-aqueous solutions. Each box includes 3 filters pre-sterilized and ready for immediate use in medical device manufacturing, pharmaceutical production, and laboratory environments.
Key Features
- Hydrophobic Membrane: Optimized for non-aqueous and low-polarity liquids, with proven bacterial retention performance per ASTM F838 methodology
- Code 7 Configuration: Two-piece design (2-226) with O-rings featuring locking tabs for secure and leak-free installation
- FDA Compliance: Manufactured under Good Manufacturing Practices (GMP) and meets FDA Indirect Food Additive requirements
- Multiple Sterilization Options: Withstands up to 30 SIP cycles (30 minutes @ 135°C) and 30 autoclave cycles (60 minutes @ 126°C)
- Low Endotoxin Levels: Bacterial endotoxin content ≤0.5 EU/mL by LAL test, suitable for injectable formulations
Technical Specifications
| Filter Specifications | |
| Pore Size | 0.22 µm (nominal) |
| Wettability | Hydrophobic |
| Device Configuration | Cartridge (Code 7, 2-226 O-rings with locking tabs) |
| Quantity Per Box | 3 filters |
| Performance Specifications | |
| Max Differential Pressure (Forward @ 25°C) | 5.5 bar (80 psid) |
| Max Differential Pressure (Forward @ 80°C) | 1.7 bar (25 psid) |
| Max Differential Pressure (Forward @ 135°C) | 0.35 bar (5 psid) |
| Max Differential Pressure (Reverse @ 25°C) | 3.5 bar (50 psid) |
| Max Inlet Pressure (Forward @ 25°C) | 5.5 bar (80 psi) |
| Flow Rate | 50 L/min @ 1.4 bar ΔP |
| Air Diffusion (@ 23°C) | ≤13.3 mL/min @ 2.75 bar (40 psig) in water |
| Bubble Point (@ 23°C) | ≥3450 mbar (50 psig) air with water |
| Quality Level | MQ400 |
| Sterilization & Compliance | |
| SIP Cycles | 30 cycles @ 135°C for 30 minutes |
| Autoclave Cycles | 30 cycles @ 126°C for 60 minutes |
| Bacterial Endotoxins | ≤0.5 EU/mL (LAL Test) |
| Regulatory Compliance | FDA GMP; FDA Indirect Food Additive approved |
| Manufacturer | Merck Millipore (MilliporeSigma) |
Typical Applications
- Pharmaceutical Manufacturing: Sterile filtration of injectable formulations, vaccines, and biologics
- Medical Device Production: Fluid sterilization in device assembly and final package preparation
- Laboratory & QC: Sample clarification, air venting, and sterile filtration of buffers and media
- Food & Beverage: Approved for indirect food contact; used in beverage and supplement clarification
- Chemical Processing: Hydrophobic nature makes it suitable for organic solvents and non-polar liquids
Compatibility & Replacements
Compatible With
- Millipore/Merck tangential flow filtration (TFF) housings with Code 7 female receptacles
- Standard 10-inch cartridge filter holders and manifolds rated for 80 psid maximum
- Sterilization equipment capable of 135°C steam-in-place (SIP) and autoclave cycles
- GMP pharmaceutical and biotech manufacturing suites with FDA 21 CFR Part 11 documentation
Replaces / Drop-In Replacement For
- Previous-generation Millipore Durapore hydrophobic cartridge filters with identical Code 7 configuration
- Compatible alternative: Verify pressure and flow requirements before substituting other 0.22µm hydrophobic cartridges
- Note: Do not substitute CVGB71TP3 (hydrophobic) with CVGL71TP3 (hydrophilic) without validating application chemistry
Works With
- Merck/MilliporeSigma filtration systems and validation protocols
- FDA-compliant manufacturing software and batch documentation systems
- Standard filter integrity testing equipment (bubble point, diffusion)
- Autoclave and SIP sterilization control systems
